BDBM50364890 Amixin IC::TILORONE::cid_5475

SMILES CCN(CC)CCOc1ccc2-c3ccc(OCCN(CC)CC)cc3C(=O)c2c1

InChI Key InChIKey=MPMFCABZENCRHV-UHFFFAOYSA-N

Data  2 KI  9 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50364890   

TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataKi:  56nMAssay Description:Displacement of [3H]methyllylcaconitine from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]-MLA from alpha7 nicotine acetylcholine receptor in rat brain minus cerebellum after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Southern Research Institute

Curated by PubChem BioAssay
LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataIC50:  3.03E+4nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Southern Research Institute

Curated by PubChem BioAssay
LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataEC50: >5.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in xenopus oocytes by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at alpha3beta2 nAChR receptor by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at alpha4beta2 nAChR receptor by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataIC50:  4.09E+3nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Bacillus anthracis (Firmicutes))
University of Michigan

LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataIC50:  7.10E+3nMpH: 8.8Assay Description:The reaction mixture contained DNA (1.25 uM or as specified), NTP (110 uM or as specified), 50 mM NaCl, 150 mM potassium glutamate, buffer [20 mM CAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Mycobacterium tuberculosis)
University of Michigan

LigandPNGBDBM50364890(Amixin IC | TILORONE | cid_5475)
Affinity DataIC50:  6.90E+4nMpH: 8.8Assay Description:The reaction mixture contained DNA (1.25 uM or as specified), NTP (110 uM or as specified), 50 mM NaCl, 150 mM potassium glutamate, buffer [20 mM CAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed