BDBM50365537 CHEMBL1957655

SMILES Cc1csc(n1)-c1nc(CNC(=O)c2ccccc2)[nH]c1-c1ccc2OCOc2c1

InChI Key InChIKey=KLAASVUTUDBXOT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50365537   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50365537(CHEMBL1957655)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant GST-fused ALK5 using TMB substrate after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50365537(CHEMBL1957655)
Affinity DataIC50:  680nMAssay Description:Inhibition of human recombinant ALK5 activity in human A549 cells assessed as TGFbeta-induced smad2/3 phosphorylation after 2 hrs by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed