BDBM50370476 Combivir::ZIDOVUDINE TRIPHOSPHATE

SMILES Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO[P@@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O

InChI Key InChIKey=GLWHPRRGGYLLRV-XLPZGREQSA-N

Data  3 KI  22 IC50  7 Kd

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50370476   

TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50370476(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Affinity DataIC50:  300nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50370476(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Affinity DataIC50:  420nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50370476(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Affinity DataIC50:  80nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type LAI by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50370476(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Affinity DataIC50:  130nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed