BDBM50375607 CHEMBL259218

SMILES Cc1ccc(Nc2c(Cl)cccc2Cl)c(CC(O)=O)c1

InChI Key InChIKey=ZDDWMWKQAQNCBL-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50375607   

TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt Institute For Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50375607(CHEMBL259218)
Affinity DataKi:  820nMAssay Description:Inhibition of mouse COX2 pre-incubated before addition of [1-14C]arachidonic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt Institute For Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50375607(CHEMBL259218)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of human COX2 preincubated before addition of [1-14C]arachidonic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt Institute For Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50375607(CHEMBL259218)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of ovine COX1 pre-incubated before addition of [1-14C]arachidonic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt Institute For Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50375607(CHEMBL259218)
Affinity DataIC50:  47nMAssay Description:Inhibition of human COX2 for 20 mins pre-incubated before addition of [1-14C]arachidonic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt Institute For Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50375607(CHEMBL259218)
Affinity DataIC50:  200nMAssay Description:Inhibition of purified mouse COX-2 assessed as inhibition of PGE2/PGD2 formation preincubated for 3 mins before arachidonic acid substrate addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt Institute For Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50375607(CHEMBL259218)
Affinity DataIC50:  30nMAssay Description:Inhibition of purified mouse COX-2 assessed as inhibition of PGE2-G/PGD2-G formation preincubated for 3 mins before 2-AG substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt Institute For Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50375607(CHEMBL259218)
Affinity DataIC50:  47nMAssay Description:Inhibition of human COX2 for 17 mins pre-incubated before addition of [1-14C]arachidonic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt Institute For Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50375607(CHEMBL259218)
Affinity DataIC50:  63nMAssay Description:Inhibition of mouse COX2 for 17 mins pre-incubated before addition of [1-14C]arachidonic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt Institute For Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50375607(CHEMBL259218)
Affinity DataIC50:  63nMAssay Description:Inhibition of mouse COX2 for 20 mins pre-incubated before addition of [1-14C]arachidonic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed