BDBM50386430 CHEMBL2047536

SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4ccnn34)C(=O)NCc3ccc4OCC(=O)Nc4c3)c2ccc1C(O)=O

InChI Key InChIKey=DACARRUBIAXSBX-IBGZPJMESA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50386430   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386430(CHEMBL2047536)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human recombinant aggrecanase 1 using aggrecan-IGD as substrate measured after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386430(CHEMBL2047536)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant MMP7 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386430(CHEMBL2047536)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant MMP2 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386430(CHEMBL2047536)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of human recombinant MMP3 using MCAArg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(DNP)-NH2 as substrate preincubated for 10 mins measured by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386430(CHEMBL2047536)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant MMP1 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50386430(CHEMBL2047536)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of MMP-13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386430(CHEMBL2047536)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant MMP9 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386430(CHEMBL2047536)
Affinity DataIC50:  655nMAssay Description:Inhibition of human recombinant MMP12 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50386430(CHEMBL2047536)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human recombinant MMP13 using MCA-Pro-Cha-Gly-Nva-His-Ala-Dpa-NH2 as substrate preincubated for 10 mins measured by fluorescence analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386430(CHEMBL2047536)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant MMP14 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386430(CHEMBL2047536)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant TACE using MCA-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 as substrate preincubated for 10 mins measured by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Alantos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386430(CHEMBL2047536)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human recombinant MMP8 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed