BDBM50393248 CHEMBL1258005

SMILES Brc1ccc(cc1)C(=O)N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1

InChI Key InChIKey=RPYCUDHNQUMCME-RBUKOAKNSA-N

Data  6 KI  1 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50393248   

TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataKi:  6nMAssay Description:Binding affinity to human alpha7 nAChR expressed in HEK293 cells co-expressing RIC3 cDNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]epibatidine form human alpha7 nAchR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataKi:  11nMAssay Description:Binding affinity to alpha7 nAChR in rat hippocampal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataKi:  13.2nMAssay Description:Displacement of [3H]-MLA from human alpha7 nAChR expressed in human SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataKi:  89.1nMAssay Description:Displacement of [3H]epibatidine from Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataKi:  900nMAssay Description:Displacement of [3H]nicotine human alpha4beta2 nAChR in SH-EP1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataEC50:  60nMAssay Description:Agonist activity at rat alpha7 nAchR expressed in GH4C1 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataEC50:  50nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataKd:  93nMAssay Description:Binding affinity to Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system by surface plasmon resonance biosensor assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed