BDBM50393455 CHEMBL2159691

SMILES Fc1ccc(F)c2c1OC[C@H]1[C@H](CCC#N)OCC[C@@]21S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=YBMCEYFBYSXPGP-XERREHJYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50393455   

TargetPresenilin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393455(CHEMBL2159691)
Affinity DataIC50:  37nMAssay Description:Inhibition of PS1 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393455(CHEMBL2159691)
Affinity DataIC50:  16nMAssay Description:Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393455(CHEMBL2159691)
Affinity DataIC50:  22nMAssay Description:Inhibition of PS1 gamma-secretase assessed as reduction of amyloid beta-40 production by membrane based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed