BDBM50394796 CHEMBL2163410

SMILES CN1CCN(CCO[C@@H]2CCN(CC(=O)Nc3ccc(Sc4nc(Nc5cc(C)[nH]n5)c5cccn5n4)cc3)C2)CC1

InChI Key InChIKey=UMXZZNNMKDFYAG-HSZRJFAPSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50394796   

TargetAurora kinase B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50394796(CHEMBL2163410)
Affinity DataIC50:  169nMAssay Description:Inhibition of Aurora kinase B-mediated histone H3 Ser10 phosphorylation in human HCT116 cells after 2 hrs by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50394796(CHEMBL2163410)
Affinity DataKd:  13nMAssay Description:Inhibition of Aurora kinase A autophosphorylation in human HEK293 cells after 2 hrs by phosphor antibody readout assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50394796(CHEMBL2163410)
Affinity DataKd:  2.90nMAssay Description:Binding affinity to Aurora kinase B catalytic domain by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed