BDBM50396022 CHEMBL2169920
SMILES Oc1ccc(CCNCCN(C2CCCCC2)C(=O)CCNCCc2ccc(Cl)c(Cl)c2)c2OCC(=O)Nc12
InChI Key InChIKey=LIBVHXXKHSODII-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50396022
Affinity DataKi: 300nMAssay Description:Competitive binding affinity to full length human SMYD2 amino acid 1 to 433 expressed in Escherichia coli BL21 (DE3) after 90 mins by radioactive fil...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 2.00E+4nMAssay Description:Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of SMYD2 (unknown origin) using biotinylated GSRAHSSHLKSKKGQSTSRH as substrate assessed as incorporation of tritium labeled methyl group f...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant full-length human SMYD2 (1 to 433) expressed in Escherichia coli BL21Star(DE3) cells using p53 peptide as substrate after 9...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of SMYD2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using Biotinaminohexanoyl-GSRAHSSHLKSKKGQSTSRH as substrate after 75 mi...More data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of SMYD2 (unknown origin) expressed in human U2OS cells assessed as reduction in p53 methylation by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of SMYD2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using Biotinaminohexanoyl-GSRAHSSHLKSKKGQSTSRH as substrate after 75 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of N-terminal 2xc-myc-tagged human SMYD2 transfected in human MDA-MB-231 cells assessed as reduction in AHNAK methylation after 72 hrs by ...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of full length human SMYD2 amino acid 1 to 433 expressed in Escherichia coli BL21 (DE3) using Biotinaminohexanoyl- GSRAHSSHLKSKKGQSTSRH as...More data for this Ligand-Target Pair
Affinity DataKd: 500nMAssay Description:Binding affinity to full length human SMYD2 (1 to 433 residues) expressed in Escherichia coli strain BL21 (DE3) by ITC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of full length human SMYD2 (1 to 433 residues) expressed in Escherichia coli strain BL21 (DE3) using p53 (361 to 380 residues) and [3H]-SA...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Zhejiang University
Curated by ChEMBL
Zhejiang University
Curated by ChEMBL
Affinity DataIC50: >83nMAssay Description:Inhibition of SMYD3 (unknown origin) using p53 (361 to 380 residues) and [3H]-SAM as substrate incubated for 90 mins by SPA assayMore data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+5nMAssay Description:Inhibition of FLAG-tagged SMYD2 (unknown origin) expressed in human U2OS cells mediated intracellular p53 methylation incubated for 24 hrs using p53 ...More data for this Ligand-Target Pair
Affinity DataKd: 5.00E+5nMAssay Description:Competitive inhibition of SMYD2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of SMYD2 (unknown origin) using 3H-SAM as substrate incubated for 1 hr by filter binding methodMore data for this Ligand-Target Pair
Affinity DataKd: 500nMAssay Description:Binding affinity to recombinant human full-length SMYD2 (1 to 433) by ITC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human full-length SMYD2 (1 to 433) using biotin-aminohexanoyl GSRAHSSHLKSKKGQSTSRH as substrate after 75 mins by AlphaScree...More data for this Ligand-Target Pair