BDBM50397078 CHEMBL2171452
SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)C1(C)C
InChI Key InChIKey=JPXAIORZGBCHIB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50397078
TargetDNA (cytosine-5)-methyltransferase 3A(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataKi: 3.70E+3nMAssay Description:Mixed type inhibition of human DNMT3A using AdoMet as substrateMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 3A(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataKi: 5.03E+3nMAssay Description:Binding affinity to human DNMT3A catalytic domain assessed as inhibition of enzyme-mediated DNA methylation using 3H-AdoMet as substrate incubated fo...More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 3A(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataKi: 1.26E+4nMAssay Description:Mixed type inhibition of human DNMT3A using poly dl-dC as substrateMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 3A(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataKi: 2.16E+4nMAssay Description:Binding affinity to human DNMT3A catalytic domain assessed as inhibition of enzyme-mediated DNA methylation using poly dl-dC as substrate incubated f...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Vu University Amsterdam
Curated by ChEMBL
Vu University Amsterdam
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human PDE4A1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...More data for this Ligand-Target Pair
3D Structure (crystal)TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Vu University Amsterdam
Curated by ChEMBL
Vu University Amsterdam
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human PDE4B1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Vu University Amsterdam
Curated by ChEMBL
Vu University Amsterdam
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human PDE4C1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Vu University Amsterdam
Curated by ChEMBL
Vu University Amsterdam
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human PDE4D3 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of Trypanosoma brucei His-tagged catalytic domains of TbrPDEB1 expressed in Escherichia coli BL21 assessed as conversion of cAMP to AMP af...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of Leishmania major recombinant PDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proxim...More data for this Ligand-Target Pair