BDBM50397292 CHEMBL454890::VUF-10499

SMILES CN1CCN(CC1)c1nc(NCc2ccoc2)c2cc(Cl)ccc2n1

InChI Key InChIKey=VCADIWSEVTZZOR-UHFFFAOYSA-N

Data  5 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50397292   

Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397292(CHEMBL454890 | VUF-10499)
Affinity DataKi:  2.82nMAssay Description:Displacement of [3H]granisetron from 5HT3A receptor expressed in HEK293 cells after 24 hrs by scintillation counting in presence of quipazineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397292(CHEMBL454890 | VUF-10499)
Affinity DataKi:  24.6nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397292(CHEMBL454890 | VUF-10499)
Affinity DataKi:  26.9nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397292(CHEMBL454890 | VUF-10499)
Affinity DataKi:  89.1nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397292(CHEMBL454890 | VUF-10499)
Affinity DataKi:  97.7nMAssay Description:Displacement of [3H]mepyramine from human histamine H1 receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397292(CHEMBL454890 | VUF-10499)
Affinity DataIC50:  145nMAssay Description:Inverse agonist activity at human histamine H4 receptor expressed in HEK293T cells by CRE-beta-galactosidase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed