BDBM50399672 CHEMBL2178342

SMILES ONC(=O)c1cccc(c1)-c1cn(CSc2ccccc2)nn1

InChI Key InChIKey=DORPIZJGSLWDIY-UHFFFAOYSA-N

Data  10 IC50  2 Kd

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50399672   

TargetHistone deacetylase 6(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50399672(CHEMBL2178342)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of HDAC6 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50399672(CHEMBL2178342)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of HDAC4 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50399672(CHEMBL2178342)
Affinity DataIC50:  70nMAssay Description:Inhibition of HDAC8 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50399672(CHEMBL2178342)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50399672(CHEMBL2178342)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of HDAC1 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50399672(CHEMBL2178342)
Affinity DataIC50:  6.80E+4nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50399672(CHEMBL2178342)
Affinity DataIC50:  95nMAssay Description:Inhibition of Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluoro...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50399672(CHEMBL2178342)
Affinity DataIC50:  746nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 mL6/L179I mutant expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50399672(CHEMBL2178342)
Affinity DataIC50:  628nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 mL1/mL6/L179I mutant expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50399672(CHEMBL2178342)
Affinity DataKd:  90nMAssay Description:Binding affinity to human His-thioredoxin-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50399672(CHEMBL2178342)
Affinity DataKd:  82nMAssay Description:Binding affinity to Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells by ITC methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50399672(CHEMBL2178342)
Affinity DataIC50:  44nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluorome...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed