BDBM50410949 CHEMBL210835

SMILES FC(F)(F)c1cccc(c1Cl)-n1nnnc1Cc1cccnc1

InChI Key InChIKey=FFRBXZXABYMLJL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50410949   

TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50410949(CHEMBL210835)
Affinity DataIC50:  50.1nMAssay Description:Antagonist activity at rat P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of calcium flux by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50410949(CHEMBL210835)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50410949(CHEMBL210835)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of calcium flux by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed