BDBM50426567 BMS-204352::FLINDOKALNER::MaxiPost

SMILES COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F

InChI Key InChIKey=ULYONBAOIMCNEH-HNNXBMFYSA-N

Data  5 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50426567   

TargetPotassium voltage-gated channel subfamily KQT member 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426567(BMS-204352 | FLINDOKALNER | MaxiPost)
Affinity DataEC50:  2.40E+3nMAssay Description:Positive modulatory activity at voltage-gated K channel 7.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426567(BMS-204352 | FLINDOKALNER | MaxiPost)
Affinity DataEC50:  2.40E+3nMAssay Description:Positive modulatory activity at voltage-gated K channel 7.4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426567(BMS-204352 | FLINDOKALNER | MaxiPost)
Affinity DataEC50:  2.40E+3nMAssay Description:Positive modulatory activity at voltage-gated K channel 7.3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426567(BMS-204352 | FLINDOKALNER | MaxiPost)
Affinity DataEC50:  2.40E+3nMAssay Description:Positive modulatory activity at voltage-gated K channel 7.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50426567(BMS-204352 | FLINDOKALNER | MaxiPost)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50426567(BMS-204352 | FLINDOKALNER | MaxiPost)
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50426567(BMS-204352 | FLINDOKALNER | MaxiPost)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50426567(BMS-204352 | FLINDOKALNER | MaxiPost)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50426567(BMS-204352 | FLINDOKALNER | MaxiPost)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium-activated potassium channel subunit alpha-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426567(BMS-204352 | FLINDOKALNER | MaxiPost)
Affinity DataEC50:  352nMAssay Description:Positive modulation of Kca 1.1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed