BDBM50427138 CHEMBL2323775::MK-8033
SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4ccccn4)cc3c(=O)c2c1
InChI Key InChIKey=VMJFTOSOFDEKTM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50427138
Affinity DataKd: 2.80E+4nMAssay Description:Briefly, 5 mg of a protein mixture of the four cell lines or a single cell line were incubated with compound dilution series in DMSO (3 nM, 10 nM, 30...More data for this Ligand-Target Pair
Affinity DataIC50: 582nMAssay Description:Inhibition of c-MET (unknown origin) expressed in human GTL16 cells assessed as inhibition of cell proliferationMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of HGF-stimulated c-MET (unknown origin) autophosphorylation at tyrosine 1349 expressed in human GTL16 cells after 2 hrs by Western blotti...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of RON (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-MET activation (unknown origin) expressed in human HCT116 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of RON (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 3.20nMAssay Description:Binding affinity to phosphorylated c-MET kinase domain (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.62E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate by LC-MS-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Binding affinity to unphosphorylated c-MET kinase domain (unknown origin)More data for this Ligand-Target Pair