BDBM50429202 LYNGBYASTATIN 7

SMILES CCCCCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccccc2)N2[C@H](O)CC[C@H](NC(=O)\C(NC1=O)=C\C)C2=O)C(C)C

InChI Key InChIKey=DZIGKKCSWPSVIO-SWEGFNRNSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50429202   

TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429202(LYNGBYASTATIN 7)
Affinity DataIC50:  23nMAssay Description:Inhibition of human neutrophil elastase assessed as proteolysis using N-(methoxysuccinyl)-Ala-Ala-Pro-Val-p-nitroanilide substrate incubated for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429202(LYNGBYASTATIN 7)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of pig pancreatic elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429202(LYNGBYASTATIN 7)
Affinity DataIC50:  28nMAssay Description:Inhibition of elastase in human neutrophil using N-(OMe-succinyl)-Ala-Ala-Pro-Val-p-nitroanilide as substrate preincubated with enzyme for 15 mins fo...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429202(LYNGBYASTATIN 7)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of elastase in human neutrophil using MeOSuc-AAPV-AMC as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKallikrein-7(Homo sapiens (Human))TBA
LigandPNGBDBM50429202(LYNGBYASTATIN 7)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human recombinant kallikrein 7 (23 to 252 residues) using MCA-RPKPVE-Nval-WRK(Dnp)-NH2 as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50429202(LYNGBYASTATIN 7)
Affinity DataIC50:  29nMAssay Description:Inhibition of human neutrophil elastase using N-(OMe-succinyl)-Ala-Ala-Pro-Val-p-nitroanilide as substrate incubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed