BDBM50429763 CHEMBL229844::N-(4-Hydroxyphenyl)Cinnamamide::US11135207, Example 4

SMILES Oc1ccc(NC(=O)\C=C\c2ccccc2)cc1

InChI Key InChIKey=WSRJZGPYPSPGLJ-IZZDOVSWSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50429763   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Nanjing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429763(CHEMBL229844 | N-(4-Hydroxyphenyl)Cinnamamide | US...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human recombinant MMP2 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM50429763(CHEMBL229844 | N-(4-Hydroxyphenyl)Cinnamamide | US...)
Affinity DataIC50:  440nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Nanjing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429763(CHEMBL229844 | N-(4-Hydroxyphenyl)Cinnamamide | US...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of human recombinant MMP1 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Nanjing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429763(CHEMBL229844 | N-(4-Hydroxyphenyl)Cinnamamide | US...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of human recombinant MMP9 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed