BDBM50432765 CHEMBL2348794

SMILES C[C@H](Nc1cccc(Cl)c1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1

InChI Key InChIKey=IMBVKBZWLRXRAW-LBPRGKRZSA-N

Data  2 KI  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50432765   

TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
National Institute Of Allergy And Infectious Diseases

Curated by ChEMBL
LigandPNGBDBM50432765(CHEMBL2348794)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of human IMPDH2 using IMP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGMP reductase 2(Homo sapiens)
National Institute Of Allergy And Infectious Diseases

Curated by ChEMBL
LigandPNGBDBM50432765(CHEMBL2348794)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of human GMPR2 using GMP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
National Institute Of Allergy And Infectious Diseases

Curated by ChEMBL
LigandPNGBDBM50432765(CHEMBL2348794)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
National Institute Of Allergy And Infectious Diseases

Curated by ChEMBL
LigandPNGBDBM50432765(CHEMBL2348794)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase(Cryptosporidium parvum)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50432765(CHEMBL2348794)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase(Cryptosporidium parvum)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50432765(CHEMBL2348794)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase(Cryptosporidium parvum)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50432765(CHEMBL2348794)
Affinity DataIC50:  2nMAssay Description:Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase(Cryptosporidium parvum)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50432765(CHEMBL2348794)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Cryptosporidium IMPDH preincubated for 10 mins before substrate addition by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase(Bacillus anthracis)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50432765(CHEMBL2348794)
Affinity DataIC50:  5nMAssay Description:Inhibition of Bacillus anthracis IMPDH preincubated for 10 mins before substrate addition by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase(Cryptosporidium parvum)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50432765(CHEMBL2348794)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed