BDBM50434157 CHEMBL2381958::US9340549, 78

SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12

InChI Key InChIKey=LUYWAGVRXKSNLL-DEOSSOPVSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50434157   

TargetPoly [ADP-ribose] polymerase tankyrase-1 [1091-1325](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50:  198nMT: 2°CAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2 [946-1162](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50:  189nMT: 2°CAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP6(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PARP6 (unknown origin) using histone as substrate after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50:  200nMAssay Description:Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PARP2 (unknown origin) using histone as substrate after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PARP1 (unknown origin) using histone as substrate after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PARP3 (unknown origin) using histone as substrate after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed