BDBM50439947 CHEMBL2420310

SMILES OCCN1CCN(CC(=O)Nc2ccc(-c3cccc4c3oc(cc4=O)N3CCOCC3)c3sc4ccccc4c23)CC1

InChI Key InChIKey=QPJUVRIRYLMERM-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50439947   

TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439947(CHEMBL2420310)
Affinity DataEC50:  109nMAssay Description:Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439947(CHEMBL2420310)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439947(CHEMBL2420310)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG expressed in cisapride treated CHO cells by Ion Works assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439947(CHEMBL2420310)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439947(CHEMBL2420310)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439947(CHEMBL2420310)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439947(CHEMBL2420310)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439947(CHEMBL2420310)
Affinity DataIC50:  5nMAssay Description:Inhibition of human DNA-PK using GST-tagged p53N66 as substrate after 1 hr by ELISA-based chemiluminiscence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed