BDBM50441569 CHEMBL2436981::US10485800, Example 4::US9814704, Example 4
SMILES Nc1ccc(cn1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
InChI Key InChIKey=YVKIJUOXNIWLHR-UHFFFAOYSA-N
Data 7 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50441569
Affinity DataIC50: 1.37E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as inhibition of midazolam metabolism by HPLC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as inhibition of diclofenac metabolism by HPLC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio
Curated by ChEMBL
Califia Bio
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Califia Bio
Curated by ChEMBL
Califia Bio
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of human wild type LRRK2 by qPCR analysisMore data for this Ligand-Target Pair