BDBM50442356 CHEMBL2442885::US10357546, ND-380::US9951035, ND-380

SMILES COC(=O)Nc1ccc(Oc2ccc(cc2)S(=O)(=O)CC2CS2)cc1

InChI Key InChIKey=NKVKCTYTQNQNIH-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50442356   

Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50442356(CHEMBL2442885 | US10357546, ND-380 | US9951035, ND...)
Affinity DataKi:  50nMAssay Description:Inhibition of human recombinant MMP-2 using MOCAcPLGLA2pr(Dnp)AR-NH2 as substrate by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50442356(CHEMBL2442885 | US10357546, ND-380 | US9951035, ND...)
Affinity DataKi:  180nMAssay Description:Inhibition of human recombinant MMP-9 catalytic domain using MOCAcPLGLA2pr(Dnp)AR-NH2 as substrate by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50442356(CHEMBL2442885 | US10357546, ND-380 | US9951035, ND...)
Affinity DataKi:  180nMAssay Description:Human recombinant active MMP-2 and MMP-7, and the catalytic domains of MMP-3 and MMP-14/MT1-MMP were purchased from EMD Chemicals, Inc. (San Diego, C...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50442356(CHEMBL2442885 | US10357546, ND-380 | US9951035, ND...)
Affinity DataKi:  180nMAssay Description:The term selective inhibitor as used in reference to MMPs refers to an inhibitor that inhibits the enzymatic activity of one MMP in the presence of o...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50442356(CHEMBL2442885 | US10357546, ND-380 | US9951035, ND...)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of human recombinant MMP-14 catalytic domain using MOCAcPLGLA2pr(Dnp)AR-NH2 as substrate by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50442356(CHEMBL2442885 | US10357546, ND-380 | US9951035, ND...)
Affinity DataKi:  1.30E+4nMAssay Description:The term selective inhibitor as used in reference to MMPs refers to an inhibitor that inhibits the enzymatic activity of one MMP in the presence of o...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50442356(CHEMBL2442885 | US10357546, ND-380 | US9951035, ND...)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of human recombinant MMP-8 catalytic domain using McaKPLGL9(Dpa)AR-NH2 as substrate by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50442356(CHEMBL2442885 | US10357546, ND-380 | US9951035, ND...)
Affinity DataKi:  1.30E+4nMAssay Description:Human recombinant active MMP-2 and MMP-7, and the catalytic domains of MMP-3 and MMP-14/MT1-MMP were purchased from EMD Chemicals, Inc. (San Diego, C...More data for this Ligand-Target Pair
In DepthDetails US Patent