BDBM50445042 CHEMBL3098767::US10195186, Example 7::US9682967, 7

SMILES Cc1ccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)nc1C

InChI Key InChIKey=SYQWKHIXWNHJAX-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50445042   

TargetSortilin(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM50445042(CHEMBL3098767 | US10195186, Example 7 | US9682967,...)
Affinity DataKi:  162nM IC50:  170nMpH: 7.4Assay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM50445042(CHEMBL3098767 | US10195186, Example 7 | US9682967,...)
Affinity DataKi:  162nMAssay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM50445042(CHEMBL3098767 | US10195186, Example 7 | US9682967,...)
Affinity DataIC50:  170nMAssay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM50445042(CHEMBL3098767 | US10195186, Example 7 | US9682967,...)
Affinity DataIC50:  170nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed