BDBM50445047 CHEMBL3098760::US10195186, Example 22::US9682967, 22

SMILES OC(=O)c1cc(Br)ccc1C(=O)Nc1cccc(Cl)n1

InChI Key InChIKey=PWIQBQDVHUEOJB-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50445047   

TargetSortilin(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM50445047(CHEMBL3098760 | US10195186, Example 22 | US9682967...)
Affinity DataKi:  1.52E+3nM IC50:  1.60E+3nMpH: 7.4Assay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM50445047(CHEMBL3098760 | US10195186, Example 22 | US9682967...)
Affinity DataKi:  1.52E+3nMAssay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM50445047(CHEMBL3098760 | US10195186, Example 22 | US9682967...)
Affinity DataIC50:  1.60E+3nMAssay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSortilin(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM50445047(CHEMBL3098760 | US10195186, Example 22 | US9682967...)
Affinity DataIC50:  1.60E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed