BDBM50445521 CHEMBL3103033::US11345702, Table 1.21::US20230390274, Compound A-6
SMILES Clc1cccc(c1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
InChI Key InChIKey=XODGBXPZOXYLFN-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50445521
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.92E+3nMAssay Description:Inhibition of ALDH1A1 (unknown origin) using NAD+/propionaldehyde as substrate after 15 mins by UV-fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:The in vitro biochemical assay can be performed in white, 384 plates in total 20 μl reaction volume consisting of 10 nM of 15-PGDH/HPGD (R&D Sys...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:The in vitro biochemical assay can be performed in white, 384 plates in total 20 μl reaction volume consisting of 10 nM of 15-PGDH/HPGD (R&D Sys...More data for this Ligand-Target Pair
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:A hydroxyprostaglandin dehydrogenase inhibition screening biochemical assay can be performed to assess the synthesized inhibitors provided herein. Pr...More data for this Ligand-Target Pair