BDBM50448484 CHEMBL3126646

SMILES Cc1cc(Nc2cccc(NC(=O)c3cccc(Nc4ccnc5ccccc45)c3)c2)nc(N)n1

InChI Key InChIKey=GRGNBXUBKBUEDX-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50448484   

TargetDNA (cytosine-5)-methyltransferase 3A(Homo sapiens (Human))
Cnrs-Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50448484(CHEMBL3126646)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of His6-tagged human recombinant DNMT3a expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-bio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Cnrs-Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50448484(CHEMBL3126646)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50448484(CHEMBL3126646)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human GLP (734 to 1235) using histone as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by liqu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Cnrs-Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50448484(CHEMBL3126646)
Affinity DataIC50:  120nMAssay Description:Inhibition of human N-terminal 600 residues-deleted DNMT1 using poly(dI-dC) as substrate in presence of AdoMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 3-like(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50448484(CHEMBL3126646)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human DNMT3A2/3L using unmethylated DNA as substrate in presence of [methyl-3H]-AdoMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Cnrs-Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50448484(CHEMBL3126646)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human N-terminal 600 residues-deleted DNMT1 using hemimethylated (GAC)12 as substrate preincubated for 5 mins followed by substrate add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1(Rattus norvegicus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50448484(CHEMBL3126646)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of rat recombinant PRMT1 using histone as substrate preincubated for 5 mins followed by substrate addition measured after 6.5 mins by liqu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed