BDBM50450630 CHEMBL101896

SMILES Fc1cnccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C(F)(F)F)C(F)(F)F

InChI Key InChIKey=XZIQSOZOLJJMFN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50450630   

TargetShort transient receptor potential channel 1(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50450630(CHEMBL101896)
Affinity DataIC50:  300nMAssay Description:Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry by measuring residual activity preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium release-activated calcium channel protein 1(Rattus norvegicus)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50450630(CHEMBL101896)
Affinity DataIC50:  490nMAssay Description:Inhibition of ORAI/STIM1 in thapsigargin treated rat RBL2H3 cells assessed as reduction in store-operated calcium entry after 5 mins by fura-2-AM dye...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShort transient receptor potential channel 3(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50450630(CHEMBL101896)
Affinity DataIC50:  1.85E+4nMAssay Description:Inhibition of YFP-tagged TRPC3 (unknown origin) expressed in HEK293 cells assessed as reduction carbhocol-induced receptor operated Calcium influx af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed