BDBM50451447 CHEMBL4217988
SMILES FC(F)(F)c1cccc(c1)-c1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ncns2)c(c1)-c1ccnc(CNCCC2CCNCC2)c1
InChI Key InChIKey=WSPHMGORSRQULF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 40 hits for monomerid = 50451447
Affinity DataKi: 68nMAssay Description:Displacement of [3H]hemicholinium-3 from recombinant human choline transporter after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: 1.09E+3nMAssay Description:Displacement of [3H]Dofetilide from recombinant human ERG after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.12E+3nMAssay Description:Displacement of [3H]BTCP from recombinant human dopamine transporter after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.16E+3nMAssay Description:Displacement of [3H]nisoxetine from recombinant human norepinephrine transporter after 120 min by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.01E+3nMAssay Description:Displacement of [3H]BTCP from recombinant human dopamine transporter after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Displacement of [3H]hemicholinium-3 from recombinant human choline transporter after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.65E+3nMAssay Description:Inhibition of recombinant human COX2 using arachidonic acid as substrate measured after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.17E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.75E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 309nMAssay Description:Inhibition of human Nav1.1 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human Nav1.2 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6.44E+3nMAssay Description:Inhibition of human Nav1.3 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of human Nav1.4 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human Nav1.6 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of rat Nav1.6 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Nav1.9 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.83E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >2.52E+4nMAssay Description:Inhibition of human ERG by PatchXpress electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataEC50: 1.43E+3nMAssay Description:Agonist activity at recombinant human adenosine A1 receptor expressed in mouse BA/F3 cells assessed as increase in calcium flux by spectrophotometric...More data for this Ligand-Target Pair
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.25E+3nMAssay Description:Displacement of [3H]nisoxetine from recombinant human norepinephrine transporter after 120 min by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of human Nav1.5 by Q-patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human 5-HT1B receptor expressed in HeLa cells assessed as increase in cAMP accumulation measured after 20 mins by HTRF methodMore data for this Ligand-Target Pair