BDBM50453839 CHEMBL4209541::US10556883, Compound 18

SMILES CN(C)C(C)(C)C(=O)N1CC(CC(=O)NO)(C1)NS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1

InChI Key InChIKey=CAWAGNVJSKTWIV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50453839   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453839(CHEMBL4209541 | US10556883, Compound 18)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50453839(CHEMBL4209541 | US10556883, Compound 18)
Affinity DataIC50: >1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 ??L containing 1% DMSO. Recombinant Human catalytic domains of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453839(CHEMBL4209541 | US10556883, Compound 18)
Affinity DataIC50:  3.5nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent