BDBM50453843 CHEMBL4210459::US10556883, Compound 7b

SMILES CC(C)C(=O)N1CC(C1)(NS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO

InChI Key InChIKey=HNUAUXSTGWMXRF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50453843   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453843(CHEMBL4210459 | US10556883, Compound 7b)
Affinity DataIC50:  16nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50453843(CHEMBL4210459 | US10556883, Compound 7b)
Affinity DataIC50: >1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 ??L containing 1% DMSO. Recombinant Human catalytic domains of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453843(CHEMBL4210459 | US10556883, Compound 7b)
Affinity DataIC50:  5.20nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent