BDBM50453843 CHEMBL4210459::US10556883, Compound 7b
SMILES CC(C)C(=O)N1CC(C1)(NS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
InChI Key InChIKey=HNUAUXSTGWMXRF-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50453843
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Nestl�
Curated by ChEMBL
Nestl�
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 ??L containing 1% DMSO. Recombinant Human catalytic domains of...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Nestl�
Curated by ChEMBL
Nestl�
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair