BDBM50455873 CHEMBL4216801

SMILES Cc1c(CN2CCC(CC2)Nc2ncnc3sc(CC(F)(F)F)cc23)ccc2n(C[C@@H]3CNC(=O)CO3)c(cc12)C#N

InChI Key InChIKey=JTUOGOXWKQAKOR-NRFANRHFSA-N

Data  1 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50455873   

TargetMenin(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50455873(CHEMBL4216801)
Affinity DataIC50:  3.60nMAssay Description:Displacement of fluorescein-labeled MLL4-43 from full length human menin expressed in Escherichia coli BL21 (DE3) cells after 3 hrs by fluorescence p...More data for this Ligand-Target Pair
TargetMenin(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50455873(CHEMBL4216801)
Affinity DataKd:  10nMAssay Description:Binding affinity to human Menin expressed in Escherichia coli Rosetta2 (DE3) cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetMenin(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50455873(CHEMBL4216801)
Affinity DataKd:  9nMAssay Description:Binding affinity to human C-terminal Avi-tagged menin expressed in Escherichia coli BL21 (DE3) cells by bio-layer interferometryMore data for this Ligand-Target Pair