BDBM50457815 CHEMBL4211840

SMILES COc1cc(nc(c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O)C(N)=O

InChI Key InChIKey=LQSHXYHWYGKAMX-FQEVSTJZSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50457815   

TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataKi:  0.230nMAssay Description:Inhibition of NIK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataKi:  0.230nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataIC50:  70nMAssay Description:Inhibition of NIK in human HeLa cells assessed as inhibition of non-classical NFkB signaling by measuring reduction in nuclear translocation of p52 p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataIC50:  10nMAssay Description:Inhibition of His6-tagged human NIK (330 to 680 residues) S549D mutant expressed in baculovirus-infected Sf9 cells incubated for 30 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataIC50:  34nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of TNFalpha-induced nuclear translocation of NFkB RelA in human HeLa cells preincubated for 4.5 hrs followed by TNFalpha stimulation for 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed