BDBM50457815 CHEMBL4211840
SMILES COc1cc(nc(c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O)C(N)=O
InChI Key InChIKey=LQSHXYHWYGKAMX-FQEVSTJZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50457815
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 0.230nMAssay Description:Inhibition of NIK (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 0.230nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of NIK in human HeLa cells assessed as inhibition of non-classical NFkB signaling by measuring reduction in nuclear translocation of p52 p...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of His6-tagged human NIK (330 to 680 residues) S549D mutant expressed in baculovirus-infected Sf9 cells incubated for 30 mins in presence ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of TNFalpha-induced nuclear translocation of NFkB RelA in human HeLa cells preincubated for 4.5 hrs followed by TNFalpha stimulation for 3...More data for this Ligand-Target Pair