BDBM50457851 CHEMBL4205416

SMILES COc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3sc(nc23)-c2cccnc2)cc1

InChI Key InChIKey=RTWZCNGWNJMPBW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50457851   

TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457851(CHEMBL4205416)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457851(CHEMBL4205416)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as decrease in midazolam 1-hydroxylation by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457851(CHEMBL4205416)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human ERG by cell based automated patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50457851(CHEMBL4205416)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed