BDBM50458313 CHEMBL4217054

SMILES CCc1ccc(s1)[C@H]1N(Cc2c1[nH]c1ccccc1c2=O)c1ncc(cn1)-c1ccccn1

InChI Key InChIKey=IFMLEMDUMAPODC-XMMPIXPASA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50458313   

TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50458313(CHEMBL4217054)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50458313(CHEMBL4217054)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE5A1 catalytic domain expressed in Baculovirus infected Sf9 insect cells using FA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50458313(CHEMBL4217054)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human DNA polymerase iota using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed