BDBM50459448 CHEMBL4217599

SMILES Cc1n[nH]c(C)c1-c1cc(Cl)cc2n(Cc3cc(C)c(F)c(C)c3)c(nc12)N1CCNCC1

InChI Key InChIKey=SVULJAPKAMXBBJ-UHFFFAOYSA-N

Data  1 Kd  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50459448   

TargetSon of sevenless homolog 1(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459448(CHEMBL4217599)
Affinity DataKd: <100nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459448(CHEMBL4217599)
Affinity DataEC50:  1.56E+4nMAssay Description:Activation of SOS1 in human NCI-H727 cells expressing KRAS G12V mutant assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459448(CHEMBL4217599)
Affinity DataEC50:  9.00E+3nMAssay Description:Activation of SOS1 in human HeLa cells expressing wild type KRAS assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 mins by I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB