BDBM50459477 CHEMBL4210312
SMILES Cc1nc(N)ncc1-c1cc(Cl)cc2n(Cc3ccc(F)cc3)c(nc12)N1CC2(CNC2)C1
InChI Key InChIKey=ANXNBGIHYWKLAR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50459477
Affinity DataKd: 36nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.75E+4nMAssay Description:Activation of SOS1 in human NCI-H727 cells expressing KRAS G12V mutant assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 min...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40E+4nMAssay Description:Activation of SOS1 in human HeLa cells expressing wild type KRAS assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 mins by I...More data for this Ligand-Target Pair