BDBM50459995 CHEMBL4225966::US11471446, Compound DBA-10

SMILES Cc1c(Br)c(Br)c2CCCn3c(nc1c23)N1CCNCC1

InChI Key InChIKey=FSBMCTDYWXIBLM-UHFFFAOYSA-N

Data  13 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50459995   

TargetCyclin-dependent kinase 9(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of CDK9 (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK8/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK19/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 19(Homo sapiens (Human))
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK19/Cyclin C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 8/19(Homo sapiens (Human))
Lu License

US Patent
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataEC50:  20nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50:  37nMAssay Description:Inhibition of CDK8 (unknown origin) incubated in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of CDK8 in human HCT-116 cells transfected with TOPFlash luciferase reporter plasmid assessed as reduction in TCF/LEF transcriptional acti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-C(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of CDK8/Cyclin C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK19/Cyclin C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 19(Homo sapiens (Human))
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed