BDBM50460767 CHEMBL4228240

SMILES CCN(CCO)Cc1cc(Nc2nc(C)cn3c(cnc23)-c2cn[nH]c2)sn1

InChI Key InChIKey=RHAMYMXUVZEEJR-UHFFFAOYSA-N

Data  24 IC50  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50460767   

TargetAurora kinase B(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataEC50:  24nMAssay Description:Inhibition of Aurora B in human HCT116 cells assessed as reduction in phosphorylation of Histone H3 at Ser10 residue incubated for 1 hr by Hoechst 33...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of PLK3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetProtein kinase C alpha type(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of PKCA (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50:  180nMAssay Description:Inhibition of RSK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetAurora kinase A(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: <4nMAssay Description:Inhibition of Aurora A (unknown origin) using Tamra-PKAtide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetAurora kinase B(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: <13nMAssay Description:Inhibition of Aurora B (unknown origin) using Tamra-PKAtide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50:  13nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetEphrin type-B receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50:  100nMAssay Description:Inhibition of EPHB4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50:  5nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: <1nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of NEK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetTestis-specific serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of TSSK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCalcium/calmodulin-dependent protein kinase type IV(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of CAMK4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of GSK3b (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of IKKB (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCasein kinase I isoform delta(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of CSNK1D (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSerine/threonine-protein kinase 3(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of MST2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50460767(CHEMBL4228240)Copy SMILESCopy InChI

Affinity DataIC50: >500nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI