BDBM50462603 CHEMBL4248209::US11542283, Compound V-8A
SMILES COC[C@H](NC(=O)c1cc(Cl)ccc1Cl)C(=O)N[C@@H](CC(C)C)B1OCCNCCO1
InChI Key InChIKey=SOGYIICGUUSWIE-ROUUACIJSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50462603
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Nanjing Forestry University
Curated by ChEMBL
Nanjing Forestry University
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of caspase-like activity of human 20S proteasomeMore data for this Ligand-Target Pair
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 7.02nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University
Curated by ChEMBL
Nanjing Forestry University
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Nanjing Forestry University
Curated by ChEMBL
Nanjing Forestry University
Curated by ChEMBL
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of trypsin-like activity of human 20S proteasomeMore data for this Ligand-Target Pair