BDBM50465853 CHEMBL4283314
SMILES Cc1ccc2oc(cc(=O)c2c1)-c1ccc(OCCCCc2cn(CCOCCOc3ccc4c(c3)oc(cc4=O)-c3ccccc3)nn2)cc1
InChI Key InChIKey=IJOIRCPQRBNWJL-UHFFFAOYSA-N
Data 4 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50465853
TargetMultidrug resistance-associated protein 1(Human)
Hong Kong Polytechnic University
Curated by ChEMBL
Hong Kong Polytechnic University
Curated by ChEMBL
Affinity DataEC50: 175nMAssay Description:Inhibition of MRP1 in human 2008/MRP1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring reduction in cell survival afte...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Hong Kong Polytechnic University
Curated by ChEMBL
Hong Kong Polytechnic University
Curated by ChEMBL
Affinity DataEC50: 28nMAssay Description:Inhibition of BCRP (unknown origin) transfected in HEK293/R2 cells assessed as reversal of topotecan resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
Affinity DataEC50: 160nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Hong Kong Polytechnic University
Curated by ChEMBL
Hong Kong Polytechnic University
Curated by ChEMBL
Affinity DataEC50: 135nMAssay Description:Inhibition of BCRP in human MCF7/MX100 cells assessed as reversal of topotecan resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair