BDBM50468108 CHEMBL4280125::US11247985, Table 3.59

SMILES CC(C)N1CCN(CCNC2CCN(CC2)c2cccc(c2)-c2cc3cc(F)ccc3[nH]2)CC1

InChI Key InChIKey=LZHXZCVDLATFAR-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50468108   

TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh Chemical Diversity Center

Curated by ChEMBL
LigandPNGBDBM50468108(CHEMBL4280125 | US11247985, Table 3.59)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant full length human p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2 (DE3) using 100 uM ATP as substrate after...More data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh Chemical Diversity Center

Curated by ChEMBL
LigandPNGBDBM50468108(CHEMBL4280125 | US11247985, Table 3.59)
Affinity DataIC50:  27nMAssay Description:To optimize p97 inhibitors, the C-5 trifluoromethylated trifluoromethylated indole 12 was generated as a promising lead structure. In the ADP-Glo ass...More data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh Chemical Diversity Center

Curated by ChEMBL
LigandPNGBDBM50468108(CHEMBL4280125 | US11247985, Table 3.59)
Affinity DataIC50:  20nMAssay Description:Inhibition of human p97More data for this Ligand-Target Pair