BDBM50468112 CHEMBL4277404::US11247985, Table 3.63

SMILES CC(C)N1CCN(CC1)C1(CNC2CCN(CC2)c2cccc(c2)-c2cc3cc(F)ccc3[nH]2)COC1

InChI Key InChIKey=UTPLVVVRULZSDS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50468112   

TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University of Pittsburgh

US Patent
LigandPNGBDBM50468112(CHEMBL4277404 | US11247985, Table 3.63)
Affinity DataIC50:  41nMAssay Description:To optimize p97 inhibitors, the C-5 trifluoromethylated trifluoromethylated indole 12 was generated as a promising lead structure. In the ADP-Glo ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University of Pittsburgh

US Patent
LigandPNGBDBM50468112(CHEMBL4277404 | US11247985, Table 3.63)
Affinity DataIC50:  90nMAssay Description:Inhibition of recombinant full length human p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2 (DE3) using 100 uM ATP as substrate after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed