BDBM50468574 CHEMBL4116008::US11414410, Example 100

SMILES CCS(=O)(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1

InChI Key InChIKey=BGLPECHZZQDNCD-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50468574   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50:  8nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50:  12nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50:  6nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Alexion Pharmaceuticals

US Patent
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50:  55nMAssay Description:The kinase reaction is performed in a black U-bottom 96-well microtitre plate. The final reaction volume is 50 μL and contains a final concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50:  6nMAssay Description:Inhibition of JAK 2 (unknown origin)More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))TBA
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50:  12nMAssay Description:Inhibition of JAK 1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50:  4nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50:  6nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50:  8nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50:  12nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50:  8nMAssay Description:Inhibition of JAK 3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed