BDBM50485974 CHEMBL2180376

SMILES COc1cc(\C=C2/CCCN3[C@H](CON=C23)c2ccc(F)cc2)ccc1-n1cnc(C)c1

InChI Key InChIKey=IQTCDSQBHHTVBN-GAISBVLPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50485974   

TargetPresenilin-1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50485974(CHEMBL2180376)
Affinity DataIC50:  33nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50485974(CHEMBL2180376)
Affinity DataIC50:  37nMAssay Description:Modulation of gamma-secretase expressed in HEK293 cells co-expressing APPsw-lon assessed as reduction of amyloid-beta-42 level by sandwich immunoassa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed