BDBM50488818 CHEMBL2295958

SMILES CC(C)C(O)Nc1nc(Nc2ccc(cc2)-c2cncnc2)c2ncn(C(C)C)c2n1

InChI Key InChIKey=FHDFIUFWMGMGTR-UHFFFAOYSA-N

Data  5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50488818   

TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))TBA

LigandBDBM50488818(CHEMBL2295958)Copy SMILESCopy InChI

Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant CDK2/cyclin A using histone H1 and [gamma33P]ATP as substrate after 30 min by scintillation countingMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

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TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))TBA

LigandBDBM50488818(CHEMBL2295958)Copy SMILESCopy InChI

Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant CDK5/p25 using histone H1 and [gamma33P]ATP as substrate after 30 min by scintillation countingMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

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TargetCasein kinase 1, delta tv1(Sus scrofa)TBA

LigandBDBM50488818(CHEMBL2295958)Copy SMILESCopy InChI

Affinity DataIC50:  500nMAssay Description:Inhibition of Sus scrofa (pig) casein kinase 1delta/epsilon isolated from brain using RRKHAAIGpSAYSITA and [gamma33P]ATP as substrate after 30 min by...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/TrEMBL
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Ligand InfoPC cidPC sid

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TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Sus scrofa)TBA

LigandBDBM50488818(CHEMBL2295958)Copy SMILESCopy InChI

Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of Sus scrofa (pig) glycogen synthase kinase 3alpha/beta isolated from brain using YRRAAVPPSPSLSRHSSPHQpSEDEEE and [gamma33P]ATP as substr...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sid

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TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

LigandBDBM50488818(CHEMBL2295958)Copy SMILESCopy InChI

Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of Homo sapiens (human) recombinant GST-tagged DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ and [gamma33P]ATP as substrate af...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails Article
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