BDBM50499290 CHEMBL3734797

SMILES Cc1noc(n1)[C@H]1C[C@@H]1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC(C)(C)C

InChI Key InChIKey=XKDFZZUFCHOVRN-GOTSBHOMSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50499290   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50499290(CHEMBL3734797)
Affinity DataIC50:  2nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 cell membranes assessed as triolein formation by LC/MS/MS analysis using oleoyl-CoA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50499290(CHEMBL3734797)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MGAT2 by CPM assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50499290(CHEMBL3734797)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human DGAT1 by CPM assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50499290(CHEMBL3734797)
Affinity DataIC50:  2.34E+3nMAssay Description:Displacement of [35S]-MK-0499 from human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1F(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50499290(CHEMBL3734797)
Affinity DataIC50:  800nMAssay Description:Inhibition of voltage-gated calcium channel (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50499290(CHEMBL3734797)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Merck

Curated by ChEMBL
LigandPNGBDBM50499290(CHEMBL3734797)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse DGAT1 by CPM assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50499290(CHEMBL3734797)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50499290(CHEMBL3734797)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse MGAT2 by CPM assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50499290(CHEMBL3734797)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MGAT2 (unknown origin) by CPM assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50499290(CHEMBL3734797)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed