BDBM50505332 CHEMBL4567515
SMILES Cl.Cc1cc(F)cc2c1nc([nH]c2=O)-c1ccc(cc1)C1CCNCC1
InChI Key InChIKey=RYCYAEKBALFRQX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50505332
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataKi: 6.80E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by whole cell patch clamp methodMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataEC50: 53nMAssay Description:Inhibition of tankyrase 1/2 in human DLD1 cells assessed as increase in axin2 accumulation incubated for 24 hrs by luminex based bead assayMore data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of recombinant human full-length Myc/His-tagged Parp-1 expressed in baculovirus infected Sf21 insect cells assessed as reduction in auto-P...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair