BDBM50505494 CHEMBL4294398
SMILES Cc1ccc2oc(cc(=O)c2c1)-c1ccc(OCCOCCOCCn2cc(CCCCOc3ccc4c(c3)oc(cc4=O)-c3ccccc3)nn2)cc1
InChI Key InChIKey=JKYZGKWNGFTCMZ-UHFFFAOYSA-N
Data 4 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50505494
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hong Kong Polytechnic University
Curated by ChEMBL
Hong Kong Polytechnic University
Curated by ChEMBL
Affinity DataEC50: 33nMAssay Description:Inhibition of BCRP (unknown origin) transfected in HEK293/R2 cells assessed as reversal of topotecan resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Hong Kong Polytechnic University
Curated by ChEMBL
Hong Kong Polytechnic University
Curated by ChEMBL
Affinity DataEC50: 198nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Hong Kong Polytechnic University
Curated by ChEMBL
Hong Kong Polytechnic University
Curated by ChEMBL
Affinity DataEC50: 171nMAssay Description:Inhibition of MRP1 (unknown origin) expressed in human 2008/MRP1 assessed as reversal of doxorubicin resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hong Kong Polytechnic University
Curated by ChEMBL
Hong Kong Polytechnic University
Curated by ChEMBL
Affinity DataEC50: 46nMAssay Description:Inhibition of BCRP in human MCF7/MX100 cells assessed as reversal of topotecan resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair