BDBM50506506 CHEMBL4465833

SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2cc(F)c(cc2s1)C(=O)NCC(F)(F)F

InChI Key InChIKey=MMFLOBKIGRXPRE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50506506   

TargetEndothelial lipase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50506506(CHEMBL4465833)
Affinity DataIC50:  200nMAssay Description:Inhibition of endothelial lipase in hepatic lipase knock-out mouse plasmaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50506506(CHEMBL4465833)
Affinity DataIC50:  50nMAssay Description:Inhibition of EL in human HT1080 cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of human serum by LC/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50506506(CHEMBL4465833)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of EL in human HT1080 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatic triacylglycerol lipase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50506506(CHEMBL4465833)
Affinity DataIC50:  4nMAssay Description:Inhibition of human HL expressed in human COS7 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed