BDBM50506718 CHEMBL1098827

SMILES O\N=C1/c2ccccc2-n2c1nc1ccccc1c2=O

InChI Key InChIKey=PMNWPSRSXHKOQI-GHRIWEEISA-N

Data  2 IC50  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50506718   

TargetNT-3 growth factor receptor(Homo sapiens (Human))
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506718(CHEMBL1098827)
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to human partial length TRKC (Q531 to G825 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506718(CHEMBL1098827)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to human full-length JNK2 (M1 to Q382 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506718(CHEMBL1098827)
Affinity DataKd:  275nMAssay Description:Binding affinity to human partial length JNK3 (V28 to Q422 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10/8/9(Homo sapiens (Human))
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506718(CHEMBL1098827)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506718(CHEMBL1098827)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to human partial length TRKA (G475 to G790 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506718(CHEMBL1098827)
Affinity DataKd:  150nMAssay Description:Binding affinity to human full-length JNK1 (M1 to Q384 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506718(CHEMBL1098827)
Affinity DataKd:  3.80E+3nMAssay Description:Binding affinity to human partial length TRKB (Q547 to G838 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10/8/9(Homo sapiens (Human))
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506718(CHEMBL1098827)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed